I'd like to build 2 or 3 Rubies into one enclosure and have them all connected to a single speaker to use as a practice amp that a whole band could plug into. Is this possible, or will it cause some sort of impedance issues having the outputs more than one Ruby all going into one speaker?
Iccaros is correct. It is possible, but will give problems unless you isolate the outputs some way, like perhaps with series resistors for each output. This prevents the individual outputs from fighting each other for different instantaneous voltages, but also lowers the output. Any kind of power output tends to not play well with another power output trying to control the same thing.
Yeah but each instrument having it's own ruby would result in a more dynamic sound wouldn't it??
It depends on what you mean when you say "dynamic sound". It'll be different. But you'll get better results by having only one power amp driving the speaker whichever way you do it.
Say, have 3 ruby's, THEN mix 'em together into another power amp connected to speaker
This is by far a better idea than trying to gang the outputs. Whether it's better than mixing before one Ruby depends on other issue, like instantaneous output levels.