Most sections of any perf on a schematic, will have something in common with already available perf builds layouts...
Transistors...I simply follow the schematic's general layout, adding a space here and there for buildability and access.
Opamps is where I really like to leave some space around the IC socket. These can get tight real quick if spaces around the IC socket are not provided.
Get the schematic, and the perfboard template printout [at Runoff Groove], that way you can try drafts of your layout on paper.
I have not too much troubles anymore builing 'freehand' on perf from the schematic, just by following the simple rules laid out above^.
When I see a really tight spot, or if I need a cramped layout, I use 'upright' resistors [these only take two adjacent holes of perf spacing], or make above board connections.
Leaving enough lead above the board for the DMM's probe to touch it, is, IMO, a very good way to make debugging a whole lot easier...
If youre like me, ..Use alot of sockets for certain voicing and active components. A specific Schematic is easier to refer to...