I'm a vero guy. Some of the Perf stuff here is beautiful to me, visually. That is what I like the most, and part of why I choose perf.
I think I I prioritize compactness, simplicity, and how the final product looks visually on both sides. That's what I shoot for, and it helps a lot in building and especially debugging. while I try to be very careful and orderly, I still make a lot of mistakes, which is a factor for me. I wish I could get something half as beautiful as Rick's perf! Most perfs I have looked at prior to this thread look hideous on the underside.
I've not been doing this long, and I've only done a few veros. A month or so ago, I made up my mind to give perf a chance. I tried a small, simple circuit, even. In short time I realized I had already misplaced two resistors. Normally no big deal, except that those resistors are my traces, since it's perf! I stopped immediately. It seemed it would be harder to debug, harder to mod, and much harder to fix errors since oftentimes you are using the leads of any said mis-soldered components as traces. Similarly, I couldn't believe how much trouble it was to get parallel leads aligned under the board (as traces) so nicely but without touching each other, even with unused rows of holes between them. It seemed I would need quite of bit of of 'white space.' As a mistake-prone person and as a beginner with both, I've concluded vero makes it easier to recover from my mistakes, and less effort to make it looking nice. At least when I turn it upside down the traces are gauranteed straight.
That being said, I hate how long it takes
me to perfect a vero layout. I've been able to get them pretty tight, and increasingly more so every time I try, after doing just a few layouts. It's definitely got it's drawbacks.
I hope to soon get the guts up to buy the materials and do my own PCBs. Vero, I hope, is just what I use for now until I can make my own pcbs...which does sound like it has it's own set of hurdles!

Nothing is perfect.
Some tips that help me with vero/stripboard....I've taken to drilling track cuts in
every hole that I'm not soldering a component. It doesn't take that much longer if you've got the drill out anyway, and in the end, it makes the board look nicer to my eyes. Slightly easier to debug. Then, while I'm soldering, it makes it less likely that I'll put a component in the wrong hole, since there is more reference along the trace, less counting...etc.

cut the board: I'm not handy (read, dangerous) with the exacto knife. Since I've got no dremel and have the drill out already, I've used my drill to cut vero boards. I outline the part of the board I'm going to use by drilling all
around the said area with a small bit that makes those holes bigger, without breaking space between the holes. Then I get a significantly larger drill bit. I then drill through holes in the next row (away from the actual board area), every other hole or so, which breaks the board between the first row of holes I just enlarged.
I sand the edges down careful and/or use flat-nosed clipping pliers/nibs to straighten out the rough edges and make it a little cleaner....